Markov A. Gastrointestinal lesions among children with infectious diseases of nervous system

The thesis is devoted to the problem of gastrointestinal tract and the development of its complications among children with acute infectious of nervous system. The clinical features of gastrointestinal complications among children with acute neuroinfection are studied in the thesis. Phases of pathogenesis of these complications are researched and methods of laboratory diagnostics for the objective evaluation of functional disorders of the gastrointestinal tract are offered. 117 children with acute infectious diseases of the central nervous system were examined in this scientific work, among them: 61 (52.1%) patients were diagnosed with bacterial meningitis, 38 (32.5%) had viral meningitis and 11 (9.4 %) had viral encephalitis, 7 (6.0%) – encephalomyelopolyneuropathy. The average age (midpoint) was 4 years 5 months (from 2 months to 17 years 11 months). There were 16 kids (26.2%) of the first year of life – from 1 to 12 months – in the children’s age structure, 4 kids (6.6%) from 13 months to 2 years, 21 kids (34/4%) from 2 to 5 years, 10 kids (16,4%) from 6 to 11 years, 10 kids (16,4%) older than 12 years. There were 35 boys (57.4%) and 26 girls (42.6%). It is shown for the first time that the lesions of the gastrointestinal tract complicate the course of children’s acute neuroinfection in 70.9% of cases. Diarrhea and constipation are most commonly observed among the gastrointestinal symptoms, which are noticed in 33.3% and 48.7% of patients with acute neuroinfection. Hepatobiliary dysfunction – 39.1%, vomiting – 6.0%, abdominal distension – 6.0%, gastroparesis (gastric stasis) – 5.1%, enteroparesis – 2,6% are the other gastrointestinal symptoms among children with acute neuroinfection.