Kudriavtsev A. Morphological changes of the esophageal and gastric mucosa and motor-secretory disorders in gastroesophageal reflux disease in combination with type 2 diabetes mellitus in young people

Today there is a tendency of significant increase in the incidence of gastroesophageal reflux disease (GERD), in particular in young people (Dorofieiev A.E., 2019; Kalinichenko N. V., Dragomiretska N. V., Gushcha S. G., Zabolotna I. B., Kulchitskaya A. I., 2019; Bychkov, M.A., Yakhnytska М. М., 2019; Tkach S.M., Кuzenko Y.G., 2020). It can also be argued that among people in this age group the number of patients with GERD with concomitant type 2 diabetes mellitus (type 2 diabetes) is increasing. It should be emphasized that the long period of asymptomatic GERD, the probability of chronic recurrence and severe long-term complications necessitates in-depth study of this issue. Thus, the additional inclusion in the complex scheme of pathogenetic therapy of GERD in combination with diabetes mellitus type 2 of the hemoderivative from deproteinized calf blood contributes to a significant improvement in the clinical picture of the disease, morphological changes EM and GM, esophageal and gastric MSD, MED, GNA, PPG, OS, indicators of regional blood flow, psychosomatic disorders and QOL in young people with GERD in combination with type 2 diabetes and isolated GERD. The research addresses a relevant issue of modern clinical therapy: determining the features of the morphological state of EM and GM, esophageal and gastric MSD, indicators of OS and QOL in young people with GERD in combination with type 2 diabetes, on the basis of which we developed and introduced a new diagnostic strategy, grounded the treatment of GERD in this category of patients aimed at improving their quality of life.