Alianova T. Functional Dyspepsia: Clinical and Pathogenetic Features of the Course and Differentiated Approach to Treatment

The following dissertation paper deals with the diagnosis and treatment of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). Functional dyspepsia (FD) negatively affects patients’ quality of life and is economically demanding due to the increased spending on diagnostic and treatment measures, and the increased number of sick days at work. Standard approaches to the treatment of patients with postprandial distress syndrome and epigastric pain are only effective in 15-30% of cases. The aim of this work is to improve the diagnostics and increase the effectiveness of treatment by studying the clinical features, morphological features of the gastroduodenal area and the psychological status of patients with postprandial distress syndrome and epigastric pain. Research objectives: 1. To study and compare the features of clinical manifestations in patients with PDS and EPS. 2. To assess risk factors and the frequency of concomitant pathology in patients with PDS and EPS and their impact on the severity of symptoms of functional dyspepsia. 3. Carry out a comparative analysis of histological changes in the body of stomach and stomach antrum in patients with PDS and EPS. 4. Calculate the number of eosinophils in the gastric mucosa and duodenum in patients with PDS and EPS. 5. Assess and compare the psychological status of patients with PDS and EPS. 6. Evaluate the effectiveness of different treatment options in patients with PDS and EPS according to clinical criteria, to the results of quality of life, to the levels of anxiety and depression and develop recommendations for treatment.