Skalskyi S. Complex treatment of purulent wound using locally controlled high pressure aerosol dispersion

The new method has been developed of treatment has a comprehensive effect on the healing process and includes the measurement and correction of hydrogen index, wound treatment with sorbents, elements of hyperbaric oxygenation, improvement of the evacuation of the wound exudate, dosage delivery of drugs and maintenance of a moist environment in the wound. Patients of the main group have reported faster for 2±0.2 wound healing, early formation of granulation tissue, enhanced immune response than in the comparison group, where similar changes have been observed only on the fifth day. A decrease in the number of destructive granulocyte forms, compared with the control group by 10.14% on day 3 and 24.31% on day 5 day. Macrophages were found more in the main group by 78% on day 3, and by 211% on day 5 compared to the control group. Phagocytosis activity in the main group was higher by 33% on day 3 and by 27.2% on day 5. In the main group there was a significant quantitative reduction of microbial load on the wound by 21.64% of cases more often than in the control group after 5 days. In multicultural seedings, when re-examined, the pathogen monoculture has been detected in 81,25 % of the samples versus 37,5 % in the comparison group. The resistance of microorganisms to the antibacterial agents used after treatment in the main group was 2 times lower than in the comparison group - 15,62 % and 37,5 % of resistant strains, respectively. The difference between the hydrogen rates of wounds before the beginning and at the end of treatment was 1.67 units in the main group, 0.84 units in the comparison group. The difference in the final indicators of reduction of the area of wounds in the groups was 7,94 %, ie, the rate of closure of the wound defect at day 10 was 60% higher in the main group compared with the control one.