Gorodetsky O. Pathogenetic features of a course of periodontitis on the background of adrenaline myocardial damage and their pharmacological correction of corvitin.

The dissertation work is devoted to the study of pathological features of process violation of lipid peroxidation and antioxidant system, phagocytic activity of leukocytes, cytokines, activity of transaminases in blood, myocardium and periodontal tissues under conditions of adrenaline damage of myocardium (ADM) and experimental periodontitis (EP) separately and in their combination before and after application of corvitin. For this purpose, experimental studies were conducted on 128 white male rats kept on the standard diet of the vivarium of Danylo Halytsky Lviv National Medical University. Of which – 118 animals with experimental periodontitis and adrenaline damage of myocardium and 10 intact animals. For the first time was found the pathogenetic features of oxidative and antioxidant processes, phagocytic activity of leukocytes, cytokines and transaminases in the blood, myocardium and periodontal tissues and proven their participation in the mechanisms of adrenaline myocardial damage and experimental periodontitis. For the first time was proved the corrective effect of corvitin on impaired indicators of metabolic processes (reduced content of diene conjugates, malonic dialdehyde, phagocytic index and phagocytic number, nitroblue tetrazolium, interleukin-6, transaminases and increased activity of superoxide dismutase, catalase and ceruloplasmin, interleukin-10 in the blood myocardium and periodontal tissues) under conditions of the formation of adrenaline damage of myocardium and periodontitis. The results of the research expand the existing ideas about the pathogenesis development of adrenaline myocardiopathy and periodontitis. The pronounced corrective effect of the drug corvitin on the indicators of impaired metabolic processes indicates the expediency of its further study and use in the clinic under conditions of formation of adrenaline damage of myocardium and periodontitis and the development of guidelines.