Fedoriv A. Clinical and pathogenetic peculiarities of chronic nonbacterial prostatitis, caused herpes infection.

The work is devoted to improving the diagnosis and treatment of patients with chronic abacterial prostatitis caused by herpesvirus infection by comprehensively studying the immune response of patients to viral infection, assessing the level of cytokines in the seminal plasma of patients and justifying appropriate therapy to prove its effectiveness. The study is based on the results of examination and treatment of 146 patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CNP/CPPS) category IIIB, including 121 patients with CNP of viral etiology and 25 patients with CNP of non-viral etiology. To assess the characteristics of the immune response of patients with CNP caused by herpes and cytomegalovirus infection, the values of secretory immunoglobulin A (sIgA), interleukin 6 (IL-6) and interleukin 10 (IL-10) in ejaculate and the value of interferon-gamma (IFNγ) were analyzed in the serum of patients. The examination revealed a decrease in all of the studied indicators of immunity in patients with CNP of viral etiology compared with patients in the control groups. The above justified the need to improve the standard treatment of patients with CNP of viral etiology, taking into account the presence of the relevant pathogen in the seminal plasma (ejaculate), which led to the inclusion in the treatment of antiviral drugs and immunomodulators. The effectiveness of the proposed, compared to traditional, therapy of CNP of viral etiology has been confirmed. Evaluation of the peculiarities of the violation of the studied indicators of immunity and cytokines on CNP, viral etiology, showed their informativeness in choosing the optimal methods of treatment and monitoring its effectiveness.