Tkachenko M. Justification of complex prevention and treatment of chronic generalized catarrhal gingivitis in children with cystic fibrosis

The purpose of the study was to increase the clinical efficacy of prevention and treatment of chronic generalized catarrhal gingivitis in children with cystic fibrosis, by create a comprehensive etiotropic, therapeutic and preventive measures taken into consideration the somatic disease. For the first time, the peculiarities of the course of dental diseases among children with CF were determined, depending on the type of mutation of the CFTR gene. It has been shown that children with two mutations, different from major F508del or unknown (genotype other / others), have the highest prevalence (80 %) and intensity of dental caries (3.2±0.92). The results of clinical and laboratory studies indicate high efficacy of etiotropic and pathogenetic approach to the prevention and treatment of chronic generalized catarrhal gingivitis in children with cystic fibrosis. The monitoring the hygiene and periodontal indices, composition of the microflora of dental plaque and status of local immunity of oral cavity is practically important to establish the effectiveness of the measures and necessity for individually therapy correction.