Yurchenko A. The effect of kidney beans P. vulgaris pods aqueous extract on the development of experimental obesity in rats.

The work is devoted to the study of the influence of kidney beans (P. vulgaris) pods extract consumption on the experimental obesity development caused by a high-calorie diet. The kidney beans (P. vulgaris) pods extract consumption under experimental obesity led primarily to a decrease in body weight of experimental rats by 17% (p <0.05), despite the same amount of food consumption with animals that were only on a high-calorie diet. Accordingly, it was found the decrease of the body mass index in experimental obese rats that consumpted the studied extract on 1.3 times (p <0.05), and the weight of visceral (on 1.5 times, p <0.05) and subcutaneous on 1.6 times, p <0.05) adipose tissue compared to the same indicators in group of rats that were only on a high-calorie diet. So, the consumption of the kidney beans (P. vulgaris) pods extract showed normalization of organometric parameters under the experimental obesity development. As a result of the experiments, a positive effect of the studied extract on the carbohydrate metabolism and hormonal status indicators in animals with the experimental obesity was shown. Thus, the concentration of the animals blood glucose was decreased under consumption of the kidney beans (P. vulgaris) pods extract and high-calorie food was on 1.3 times lower (p <0.05) compared to the value in the group of rats that were only on a high-calorie diet. It is known that the glycosylated hemoglobin concentration has a direct correlation with blood glucose concentration, it was also demonstrated in our study. It was also shown that the consumption of the studied extract normalized the blood serum insulin level of animals with experimental obesity, which was higher by 22% (p <0.05) compared to the group of rats that were only on a high-calorie diet. These results can be explained by the presence of the flavonoids in bean pods, which are able to regenerate damaged pancreatic β-cells, as well as non-phenolic substances such as tannins, saponins and phytic acid, which have hypoglycemic action.