Korytskyi A. Morphological Changes in Rats’ Kidneys under Conditions of Acute and Chronic Acetylsalicylic Acid Poisoning

In the thesis paper there is given theoretical generalization and new solution of the current scientific problem to establish the features of morphological changes in the bloodstream and cellular and tissue elements of rats’ kidneys under experimental modelling of acute and chronic acetylsalicylic acid poisoning, taking into account the state of acid-base balance and blood viscosity. The complex research of kidneys morphofunctional reorganization features at white laboratory rats and their circulatory bed at organ, cellular and subcellular levels at modelling of acute and chronic poisoning with acetylsalicylic acid is carried out for the first time, the morphometric characteristic of their remodelling is given. Data on the features of the kidneys structural organization and their topography at intact rats have been updated. It was established that as a result of poisoning with acetylsalicylic acid in venous department of kidneys circulatory bed there are hemodynamic changes of stagnant nature, which can form a basis of metabolic processes disturbance with the development of dystrophic and destructive changes in the cellular elements and as a consequence – the development of renal failure. The most pronounced changes occur at acute poisoning with large doses of acetylsalicylic acid. At chronic poisoning changes are a little less expressed. There are several stages in their course: the stage of early affect, the stage of relative compensation with the stabilization of the structural organization and the period of re-progression. It was also found that one of the components in morphogenesis of pathological changes is violation of the acid-base balance with shunting of pH to the acidic side, the degree of which depends on the magnitude of toxic dose and duration of poisoning.