Barbe A. Current Approaches to Diagnose Early Stages of Peritoneal Endometriosis and Timely Treatment

In the dissertation, using an experimental model of endometriosis in rats, new approaches for the treatment of endometriosis and determining their effectiveness were established. In this work, based on clinical data, new possibilities for diagnosing the early clinical stages of peritoneal endometriosis using modern pathogenetic representations and statistical modeling have been identified. The study included experimental and clinical parts. The ideas about the pathogenesis of endometriosis have been significantly supplemented by studying the role of VEGF, MMP-2 and MMP-9 in the experiment. A pathogenetically substantiated combination of a dopamine receptor agonist (as an inhibitor of angioneogenesis) and COX-2 was tested in an experimental model of endometriosis. The activity of matrix metalloproteinases (MMPs) 2 and 9 was established simultaneously in ectopic endometrioid foci and in eutopic endometrium in patients with endometriosis. With the help of immunohistochemistry, a correlation was established between the activity of matrix metalloproteinases 2 and 9 in ectopic endometrioid foci and in eutopic endometrium. The action of a dopamine receptor agonist as a vascular growth factor inhibitor (VEGF) in experimental endometriosis was first proposed and tested.