Zavidniuk Y. Peculiarities of metabolic, neuroendocrine and immune responses to different water-salt loads

In the dissertation on the base of the study of neuroendocrine, metabolic and immune parameters of the body are provided a theoretical basis and a new solution to the scientific problem, which is to clarify the role of individual components of drinking mineral water in the formation of non-specific and specific reactions of the body in their course application. The studies were performed in the form of a chronic experiment on 58 healthy rats of Wistar line weighing 240-290 g, which were divided into 6 groups. The animals of the first group remained intact, drinking tap water from ad libitum drinkers. Rats of the second (control) group for 6 days once introduced through a tube of tap water at a dose of 1.5 ml / 100 g). In the third (reference by organic component) group daily watering of animals with water Naftussya Truskavets deposit was carried out, in the fourth (reference by salt component) group – water Sofiya Truskavets deposit. The rats of the fifth group received native Gertsa water, and the sixth – its artificial salt analogue. The cause-and-effect relationships of the course of drinking mineral water, which determine the specific and nonspecific reactions of the body to balneotherapy are revealed. It is established that regardless of the specifics of the chemical composition of the fluids used, a nonspecific reaction of the neuroendocrine-immune complex and metabolism develops, which is characterized by significant changes in the comparison with control of endocrine, metabolic and immune parameters. The significant links between the indicators of the chemical composition of irritating fluids, on the one hand, and the indicators of metabolism and neuroendocrine-immune complex, on the other hand were established. For the first time it was determined that the dominant role in revealing the specificity of the action of mineral waters belongs to organic nitrogen, carbon and microelements, and in a lesser extent – electrolytes.