Polishchuk A. Immunocytochemical characteristics of some forms of B-cell non-Hodgkin's lymphomas in the stage of leukemization

This dissertation is devoted to the study of cytomorphological, cytochemical and immunophenotypic characteristics of lymphoid cells in peripheral blood and bone marrow for assessing the extent of leukemization and differential diagnosis, especially in cases when biopsy of lymph nodes is not possible or samples from extranodal pathologic foci could not be accessible. The dissertation focuses on the comparative analysis of the cytomorphological, cytochemical and immunophenotypic characteristics of substrate cells in some forms of B-cell lymphoproliferative diseases that allows for elaboratingthe algorithms for differential diagnosis. The following forms of lymphoproliferative diseases were included into the study: chronic lymphocytic leukemia (B-CLL), small lymphocytic lymphoma (LML), monoclonal B-cell lymphocytosis (MBL); splenic diffuse red pulp small B-cell lymphoma (SDRPL), hairy cell leukemia variant (HCL-v), hairy cell leukemia (HCL), lymphoma of the marginal zone of the spleen (SMZL); mantle cell lymphoma (MCL), blastoid variant of mantle cell lymphoma (MCL-BV), and diffuse large B-cell lymphoma (DLBCL).