Demianyshyna V. Clinical and pathogenetic significance of cathelicidin and 25-hydroxycholecalciferol for assessment of severity and prognosis of cystic fibrosis course in children

According to the results of an examination of 84 patients the possibility of assessement of the severity and prediction of CF course in children based on the measurement of the level of 25 (OH) D and antimicrobial peptide cathelicidin LL-37 was detected. It was shown that patients with severe CF had significantly lower values of 25(OH)D. At the same time, in severe cases of CF the highest values of cathelicidin LL-37 were obtained. Existing data on the relationship between levels of 25 (OH) D and cathelicidin with airway colonization of P. aeruginosa have been supplemented. In children who had airway colonization with P. aeruginosa, showed significantly lower values of 25(OH)D and significantly elevated level of the antimicrobial peptide cathelicidin. It was found correlation between CFU P. aeruginosa and 25 (OH) D. The existing data on the interdependence between the levels of 25 (OH) D and cathelicidin with the indicators of the function of external respiration FEV1 have been supplemented. It was shown that deterioration of FEV1 is associated with decrease of 25 (OH) D levels, and an increase in cathelicidin levels. It was established moderate correlation between spirometry parameter FEV1 and the content of 25 (OH) D. Negative correlation between all spirometry parameters and cathelicidin level was identified. For the first time, it was shown that the suboptimal level of 25 (OH) D was associated with FEV1 less than 64% and increased risk of P. aeruginosa colonization. Patients with cathelicidin levels above 31.51 ng / ml have had increased the risk of deterioration of FEV1 less than 80% by and was associated with a positive culture of St. aureus and Ps. aeruginosa. Patients with cathelicidin content above 31.51 ng / ml were associated with significantly increased risk of severe CF.