Kachur O. Biochemical markers of oxidative stress and inflammation in the conditions of induced onconegesis after the use of cytostatics on the background of enterosorption

The dissertation is devoted to the study of metabolic disorders in experimental rats during modeling of carcinogenesis of the colon, as well as to the experimental substantiation of the expediency of using the enterosorbent AUT-M and the antitumor drug Vincristine as a means of corrective therapy. According to the results of experimental studies, new data were obtained and the existing ideas about the activity of oxidative and inflammatory processes in the conditions of experimental oncogenesis and their relationship with the development of endogenous intoxication in rats were deepened. The activity of the above processes in animals with simulated carcinogenesis of the colon and after the use of corrective agents has been studied. It was established that the conducted detoxification therapy with the use of carbonic sorbent AUT-M contributes to the normalization of free radical processes, the restoration of the body's protective and compensatory forces, in particular the antioxidant system. The adsorption capacity of the drug provides a reduction in the manifestations of endotoxicosis, which we first proved in the study of the content of molecules of medium weight - markers of endogenous intoxication. The applied sorbent provides a probable (p ≤ 0.05) reduction in the content of medium weight molecules in the serum of rats relative to animals with neoplastic endotoxicosis. The use of the cytostatic of plant origin Vincristine after entrosorption correction was proposed in the conditions of DMG-induced carcinogenesis. It is proved that this drug has little effect on the processes of lipoperoxidation and oxidative modification of proteins. Antitumor drug on the background of detoxification leads to a slight change in the activity of enzymatic and non-enzymatic parts of the antioxidant system. The model of experimental oncogenesis proved the pronounced anti-inflammatory properties of Vincristine, which was manifested by a probable (p ≤ 0.05) increase in the serum of rats of anti-inflammatory interleukin-4 (1.6 times) and a decrease in pro-inflammatory interleukin-6 (2.1 times). ), reducing the content of the early marker of inflammation of C-reactive protein (1.3 times).