Martovitsky D. Endostatin and insulin-like growth factor-I in the implementation of angiogenesis in patients with acute myocardial infarction with concomitant obesity in the dynamics of treatment

The aim of the study was to increase the effectiveness of diagnosis and treatment of patients with acute myocardial infarction with concomitant obesity based on the assessment of IGF-I and endostatin activity, as well as to study their prognostic value in the development of adverse myocardial infarction. In accordance with the purpose and objectives of the study, a comprehensive examination of 105 patients with acute myocardial infarction was performed. It was found that in 86.7% of patients with acute myocardial infarction on the background of concomitant abdominal obesity there is a multivascular lesion of the coronary arteries with a predominant number of occlusions in the proximal segments. In patients with acute myocardial infarction, there is an increase in IGF-I activity in the presence and progression of obesity and multivascular coronary artery disease. As a result, we have substantiated and practically proved that the determination of serum levels of IGF-I and endostatin in the blood of patients with AMI and obesity will help to optimize the diagnosis of AMI with comorbid obesity. Assessment of lipid metabolism in patients with AMI and obesity, taking into account the levels of IGF-I and endostatin will allow the practitioner to obtain the earliest possible criteria for the formation of metabolic disorders. Comprehensive examination of patients by echocardiography, coronary angiography and determination of levels of angiogenesis factors: IGF-I and endostatin will increase the efficiency of diagnosis and prediction of AMI with concomitant obesity.