Lysytsia Y. Clinical and pathogenetic features of the formation and progress of somatoform disorders in adolescents associated with affective states

799 children of junior and senior adolescence were examined. Control grope included 33 children. The comparative analysis showed that in children of older adolescence high and average level of situational anxiety was found 1.8 times, and personal anxiety - 5 times more often than in group of children of younger adolescence, while depressive disorders occurred in the group 2 times less often. Somatoform disorders were more common in young adolescents - in (63.6%) with a significant predominance in girls group (60.0%). It was found that pain and nonspecific somatoform disorders were most often associated with affective states: depression (48.8%), personal anxiety (95.1%), reactive anxiety (87.8%). It was found that the level of serotonin in the serum of children with somatoform disorders with depression was statistically lower, compared with children in the control group (1,03 ± 0,37 µmol/l and 1,35 ± 0,34 µmol/l (95% CI, 0,16 - 0,48 µmol/l), р<0,0002). The lowest level of serotonin was found in children with somatoform disorders of the urinary systems. Investigation of allelic polymorphisms of the 5-HTTLPR promoter link and single nucleotide (NSP) different variants of rs25531 point mutations (A / G) in the polymorphic region found that the homozygous variant of the S / S allele of the serotonin transporter 5-HTTLPR occurred 3.8 times more common than in the European population, the homozygous L/L allele was detected in only 5 (5.4%) individuals. Affective disorders occurred in 83.8% of children carrying the homozygous (S/S) variant of this gene and in 57.1% of children carrying the heterozygous (S/L) variant. The presence of the S/S allele or trial allele polymorphism SA/SG, SA/SA and Lg/Lg indicates low stress resistance of the child and an increase in the likelihood of developing somatoform disorder by 22 ± 8.20% (according to the definition of attributive risk), or 2.96 times (CR 2.96 ± 0.42 where 95% СI, 1.29 - 6.78). The L/L allele is protective against the development of affective states and somatoform disorders