Novikov Y. Features of the clinical course, changes in the electrical properties of the myocardium in patients with arterial hypertension of high additional risk with subclinical hypothyroidism and their correction

With the aim of study of the features of arterial hypertension (AH) on the background of subclinical hypothyroidism (SH), as well as the impact of statin therapy on treatment outcomes, the study involved 124 patients with AH grade 1-3, stage II, high and very high additional cardiovascular risk, of which 92 patients without and 32 patients with a concomitant SH and 16 practically healthy individuals. The diagnosis of hypertension was established in accordance with the recommendations of the Ukrainian Association of Cardiology [1], while the diagnosis of subclinical hypothyroidism in accordance with the recommendations of the European Thyroid Association [2]. Depending on therapy, patients were divided into three groups. The first group included 22 patients (54 ± 9 years, women 91 %) with AH without concomitant SH, who were prescribed only antihypertensive drugs without the addition of statins. The second group included 21 patients (56 ± 6 years, 86 % women) with AH without a concomitant SH, who were prescribed antihypertensive drugs with the addition of atorvastatin at a dose of 20-30 mg per day. The third group was formed of 32 patients (mean age 58 ± 10 years, women 90 %) with AH with a concomitant SH, who were prescribed antihypertensive drugs with the addition of atorvastatin at a dose of 20-30 mg per day. Groups of patients were comparable in age (p = 0.093), sex (p = 0.4319), height (p = 0.993), weight (p = 0.719), body surface area (p = 0.901), body mass index 0.669). All patients received a combination of two or three first-line antihypertensive drugs in average therapeutic daily doses. Determination of TSH content and tear production parameters according to the Schirmer test were conducted in patients. Before the beginning of treatment and after a year of observation, the patients underwent echocardiographic examination, scanning of the carotid arteries, 24-h monitoring of blood pressure with simultaneous ECG recording. Statistical processing was performed using the software package "STATISTICA 13.0" ("Statsoft", USA), license number JPZ8041382130ARCN10-J.