Bubir L. Optimization of diagnostics and criteria for predicting food allergy in children with the upper gastrointestinal tract pathology

Risk factors for the development of food allergy in children with the upper gastrointestinal tract pathology were identified. The structure of food sensitization in children with gastrointestinal and skin manifestations of FAH in the Poltava region was studied for the first time, taking into account the frequency and rate of reaction after consuming a suspected food item and assessing the reversibility of clinical manifestations when excluding this product from the diet by conducting a survey using the «AllergoScope» international questionnaire and through a comprehensive allergological examination. The endoscopic and morphological characteristics of UGIT lesions in patients with chronic gastritis and duodenitis against the background of IgE-induced and IgEindependent food hypersensitivity reactions were studied. Immunopathogenetic mechanisms of food hypersensitivity reactions in children with UGIT pathology taking into account the indicators of the cytokine status were studied. Correlation interrelations between the cytokine status indicators and pathomophological changes of the mucous membrane of the upper gastrointestinal tract in children with gastrointestinal manifestations of food hypersensitivity were established. The study of the serum TARC/CCL17 biomarker was performed for the first time and its diagnostic significance in the algorithm of management of patients with gastrointestinal and skin symptoms of food hypersensitivity was determined. A correlation between TARC/CCL17 and other indicators of immunological profile and histological criteria of allergic lesions of the upper digestive tract was established.