Kolianyk I. Melatonin Effect on Hydrogen Sulfide Metabolism and Liver Antioxidant System in Experimental Nephropathy

The thesis deals with investigation of melatonin effect on the indicators of the oxidant-antioxidant system state, energy metabolism and hydrogen sulfide metabolism in the liver and blood of rats under physiologically normal conditions and in experimental nephropathy. The results of our research obtained expand theoretical knowledge concerning melatonin effect produced on the development of oxidative stress, antioxidant system of the blood and liver, system of energy supply in the mitochondria of the liver cells and hydrogen sulfide metabolism, and make an experimental foundation concerning reasonability of further investigation of melatonin effect as a safe and effective means for prevention and correction of kidney and liver pathology.