Dankanych Y. Clinical and epidemiological features of chronic hepatitis C in patients with Helicobacter pylorі infection and their treatment

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0821U102510

Applicant for

Specialization

  • 222 - Медицина

26-10-2021

Specialized Academic Board

ДФ 61.051.024

Uzhhorod National University State Higher Educational Institution

Essay

For the first time, the frequency and features of lesions in Helicobacter pylori infection in patients with CHC were analyzed. For the first time, the incidence of Helicobacter pylori in patients with CHC was 34.7% and did not depend on the trophological status of the patient It was found that patients with HCG with Hp infection are 2.3 times more likely to register deeper stages of liver fibrosis (F2-3) than without Hp, which is confirmed by a direct relationship (r = 0.47; p <0.05 ) between the stages of fibrosis and the degree of Hp infection. It is established that the inclusion in the standard eradication therapy of Hp UDCA and probiotic Saccharomyces boulardii leads to a significant (p <0.05) reduction of astheno-vegetative and dyspeptic syndrome, right hypochondrium syndrome and cholestasis which improves its tolerability and increases the frequency of complete eradication of Hp.

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