Bukiy S. Improvement of the diagnosis of cytomegalovirus infection in children with shigellosis, based on the establishment of the specific features of clinical and immunological manifestations of disease.

The work presents theoretical substantiation and new solutions of the urgent issue of pediatrics, which consists in determining the pathogenetic features of the course of shigellosis in children infected with CMV, as well as in the development of an evidence-based approach to early diagnosis of CMV infection in children with shigellosis. Complex of clinical and laboratory examination was performed in 125 children from three to ten years, suffering from shigellosis, who were divided into three groups: the first group - 45 children with shigellosis without CMV infection; the second - 39 children with shigellosis and infected with CMV without signs of activity of the process (latent form of infection); the third - 41 children with shigellosis and infected with CMV (active form of infection). The scientific novelty of the obtained results consists in the addition and deepening of our knowledge of the pathogenesis of the formation of the pathological process in shigellosis in children with CMVI. For the first time, features of the clinical course of shigellosis and changes in laboratory parameters of children with different CMVI activities were identified.