Hirnyak I. Structural Changes in the Bille Ducts under the Influence of Opioids (Experimental Study)

Objects - morphological features of the bile ducts of white rats in normal and under the influence of nalbuphine; methods - corrosion; histological and electron microscopic, morphometric and statistical; results - the obtained data on the features of the architecture of the intra- and extrahepatic ducts of the white rat contribute to the formation of new ideas about the structure of the bile outflow tract of this experimental animal. The results of micro- and ultrastructural studies of the bile ducts during 6 weeks of opioid exposure allow to identify specific stages of morphological changes caused by the use of nalbuphine. The results are of practical importance for morphologists and surgeons, as they can serve as a morphological basis for the development of new methods for diagnosing, preventing and treating bile duct pathology in patients forced to use opioids for a long time, as well as in drug addicts. The results of the study of the structural features of the bile ducts of white rats in normal and experimental opioid exposure are fundamental data that researchers can rely on when studying the problems of experimental and clinical gastroenterology, abdominal surgery .