Bilyi E. Placental dysfunction prognosis in women with chronic respiratory pathology.

The dissertation is devoted to optimizing the prognosis of placental dysfunction in pregnant women with chronic respiratory pathology to prevent the development of perinatal complications. Based on a systematic approach, the features of pregnancy and childbirth in women with respiratory pathology (bronchial asthma, chronic bronchitis) were determined by assessing the biophysical profile, cardiotocography, ultrasound and Doppler changes in blood flow of the fetoplacental complex, serum angiogenesis factors (VEGF, eNOS, ET-1), morphofunctional examination of the placental system, assessment of the newborn. All clinical-laboratory and instrumental examinations were performed by standard methods using functional, ultrasound, enzyme-linked immunosorbent assays, histological methods. Appropriate methods of logical-statistical analysis with a threshold value of p-level of 0.05 were used. Based on the data of binomial regression analysis, a regression mathematical model was developed to predict the development of placental dysfunction, using clinical history, physical and biochemical parameters. The sensitivity of the developed method was 91.11 %; specificity - 93.33 %. Prognostic value of a positive result: 78.57 %. Prognostic value of a negative result: 85.71 %.