Shapoval I. Diagnostic and treatment tactics in patients with ankylosing spondylitis under conditions of comorbidity with fibromyalgia

The dissertation is a solution to the current problem of modern rheumatology and is devoted to clarifying diagnostic and treatment tactics in patients with ankylosing spondylitis (AS) in comorbidity with fibromyalgia (FM) based on the establishment of clinical features of the disease, new criteria for central sensitization and evaluation of the effectiveness of pharmacotherapy with the inclusion of duloxetine. Based on multi-stage research (general clinical, laboratory, use of specialized validation indices and scales, instrumental, enzyme-linked immunosorbent, statistical) in patients with AS established frequency of concomitant FM, assessed the consistency of diagnostic criteria for FM, established features of AS associated with AF. links with diurnal variability in plasma levels of brain-derived neurotrophic factor (BDNF), proposed criteria for determining the progression of polysymptomatic distress and predictors of resistance to treatment.