Ohinska N. Morphological changes of the cerebellum in experimental thermal trauma and under conditions of correction

The dissertation is devoted to the establishment of the peculiarities of microscopic and submicroscopic changes of the cerebellar cortex structural components in experimental burns of the skin and under the conditions of application of the lyophilized xenograft skin substrate. The experiments were conducted on 120 mature white male rats with the body weight of 180-200 g. The animals were divided into the following groups: 1st group – intact white rats; 2nd – animals with severe burns; 3rd – animals with thermal trauma, their wounds after early necrectomy of damaged skin were covered with a lyophilized xenograft skin substrate. For the first time, using a comprehensive methodological approach, morphological analysis of the structures of the cerebellar cortex after experimental thermal trauma of the skin of laboratory rats. The idea of micro- and ultrastructural rearrangement of the neuro-glial-capillary complex of all layers of the cerebellar cortex is expanded. Morphometric, microscopic and submicroscopic changes have been studied, which reveal the features of adaptive-compensatory and neurodegenerative disorders of the structural components of the cerebellar cortex, which are caused by experimental thermal trauma. It was found that the degree of morphological changes in neurons, components of the microcirculatory bed, neuroglyocytes of the cerebellar cortex of experimental animals are characterized by stages and depend on the duration of the experiment. It has been established that under the conditions of correction by use of xenograft skin substrate after early necrectomy of damaged skin areas the degree of destruction of neurones, hemocapillaries and neuroglyocytes decreases in the early stages, and in the long term active regenerative processes and normalization of structural components occur.