Storozhuk O. Diagnostic and prognostic value of pro- and anticoagulant components of hemostasis as potential predictors of thrombophilia in patients with stage VD CKD

The relationship between coagulation factors (soluble fibrin, D-dimer, fibrinogen, functionally inactive forms of prothrombin (FIFP) and anticoagulation (protein C) as well their influence on the development of thrombotic complications were established. Coagulation and fibrinolytic potentials of blood plasma in patients with stage VD CKD, their relationship with molecular markers of hemostasis, the course of the disease, as well as their prognostic value in thrombophilia development were investigated. The influence of comorbid conditions (acute inflammation, secondary hyperparathyroidism, hepatitis C and B infection) on hemostatic profile in patients with stage VD CKD was studied. Prognostic value of soluble fibrin, D-dimer, protein C and fibrinogen as possible predictors of thrombogenesis in this category of patients was determined by mathematical modeling. The most common of them were increased concentrations of soluble fibrin (68,2 %), hyperfibrinogenemia (64,7 %), protein C deficiency (56,8 %), accumulation of functionally inactive forms of prothrombin (45,5 %), while high level of D-dimer was an uncommon finding (19,3 %). By prothrombin-ecamulin ratio indices, FIFP proved to exceed 2,4 μg/ml in 42,5 % of patients demonstrating low correlation with Fg (r = 0,02) and D-d (r = - 0,15) (p ˃ 0,05), moderate negative correlation with sF (r = - 0,24) (p < 0,05) and no correlation with pC.