Antonyuk Y. Allelic polymorphism of the brain natriuretic peptide gene and the level of its plasma concentration in men with essential hypertension and chronic heart failure in the course of comorbid type 2 diabetes: diagnostic value

According to the results of the dissertation study of 211 men, residents of Podillya, including 70 patients with EH2 in combination with moderate T2DM, 62 patients with EH2 and 79 individuals without signs of cardiovascular and endocrine diseases, the scientific data about the frequency of genotypes of the BNP gene (rs 98389) distribution has been clarified. There has been demonstrated that the presence of the T381T genotype in men with T2DM associated with higher plasma levels of postprandial glucose and more significant deviations of such hemodynamic parameters as higher pulse pressure, more significant diastolic disorders of myocardial function in comparison with those who had C allele. Thus, scientific data that the TT genotype is an unfavorable polymorphic variant of the BNP gene for the development of worse shifts in intracardiac hemodynamics and glucose metabolism have been confirmed. Regardless of the carrier of the genotype of coding gene in the comorbid course of EH and T2DM levels of BNP were significantly higher than in patients with of EH2 alone and in healthy individuals. The results of the study allowed us to identify first the adjusted cut-off point of BNP level in patients with comorbid EH2, the application of which can improve its test characteristics as an indicative surrogate marker for early diagnosis of HFpEF in these patients. We have determined the levels of circulating BNP depending on the carrier of the polymorphic variant of the coding gene in men. TT homozygotes with EH2 and T2DM had lower plasma levels of BNP compared with the carriers of the C allele, but it was statistical trend. However, there was a significant difference between plasma levels of BNP in patients having EH2 alone. We have identified phenotypic features of the patient's with EH2 and T2DM portrait, which associated with a high risk of HFpEF and consisted of elevated level of BNP, increased pulse pressure, concentric hypertrophy and left ventricular diastolic dysfunction.