Pohorielova O. Optimization of prediction and increase of treatment effectiveness of pulmonary tuberculosis based on the study of β-defensin-1

The dissertation is solving the current issue of phthisiology – increasing the effectiveness of predicting the course of tuberculosis and treatment of patients with pulmonary tuberculosis based on the study of the dynamics of β-defensin-1. The dissertation is devoted to the decision of a topical question of phthisiology - increase of efficiency of forecasting of a course of tuberculosis and treatment of patients with pulmonary tuberculosis on the basis of studying of dynamics of β-defensin-1. It was found that high levels of β-defensin-1 at the beginning of treatment are associated with greater severity of tuberculosis and less effective treatment, which suggests the possibility of its use as a prognostic marker. Using the obtained data, mathematical models for predicting the effectiveness of the intensive phase of treatment, quality of life and functioning of the hepatobiliary system were developed. Against the background of the appointment of an essential amino acid complex, a comparison of β-defensin-1 levels in the groups after 2 months showed a higher level in patients who did not receive additional amino acid complex. Patients who received an essential amino acid complex completed the intensive phase of treatment with higher effectiveness (88.0%) than patients who did not receive it (60.0%). The appointment of a complex of essential amino acids improved the quality of life. In patients who did not receive additional therapy, treatment interruptions occurred in 30% of cases against 8% of cases in patients who received essential amino acids. It was found that the appointment of essential amino acids improves liver function in patients with tuberculosis.