Chaikovska O. The electrical activity and histochemical characteristics of lateral septum during acute alcohol intoxication in experimental study

This dissertation is devoted to revealing the neurophysiological mechanisms of neural networks disfunction during acute ethanol intoxication. This study was focused on electrical and histochemical characteristics of lateral septum and its reactions on acute alcohol intoxication in rat models. The data about alcohol-induced changes in oscillatory and arrhythmic activity in lateral septum together with the activation of nitrergic system received prove the hypothesis that lateral system is involved in early reaction of central nervous system during acute alcohol intoxication. We proposed new term «septogram». For the first time, septograms were recorded during acute alcohol intoxication. In addition, the arrhythmic activity of lateral septum was described and its reaction on acute alcohol intoxication. The response of nitrergic system on acute alcohol intoxication was registered and on selective blockage of neuronal NOS by 7-nitroindazole in lateral septum.