Pankiv M. Morphological features of structural components of the intervertebral disc in health and experimental opioid exposure (experimental research).

This dissertation deals with the experimental confirmation of study of the effect of narcotic analgesic nalbuphine on the structural components to reseach the intervertebral disc in health and their changes in different terms of experimental opioid exposure. Using a complex of macroscopic (preparation, skeletization), morphological (microscopic, ultramicroscopic, morphometric), experimental (modeling of opioid exposure) and statistical methods were first established and compared with a subsequent description of the features of the structural components of the rat intervertebral disc in health and pathomorphological changes at different terms of experimental opioid exposure during 56 days of experimental research.The results of the conducted studies will make it possible to create a fundamental morphological basis for further experimental research of the pathological effect of opioid group drugs on systems and organs in order to further develop practical recommendations on the duration and dosage when using drugs of this group. The results of our work are of practical importance for experimental morphology, surgical traumatology, anesthesiology and addictiology, since they can be a pathomorphological and morphological basis for the development of new methods for differential diagnosis, prevention and treatment of possible toxic opioid exposures on the structural components of the intervertebral disc among drug-addicted patients. The results obtained concerning the dynamics of changes in the structure of intervertebral disc components during experimental opioid exposure are a fundamental morphological basis, the data of which can be used in their research by morphologists when studying the issues of experimental toxic effects on the structural components of the intervertebral disc and practical trauma surgeons in the treatment of patients with spinal lesions belonging to this nosological group.