Bilous M. Improvement of methods of organ-preserving operations at traumatic injuries of a spleen

This study is based on the analysis of the results of a comprehensive clinical-instrumental and laboratory dynamic examination and evaluated the effectiveness of the proposed method of prevention and treatment in a cohort prospective randomized open clinical study in 114 patients with splenic trauma. The experimental part was performed on 89 laboratory rats, which were injected with immunocorrectors (Polyoxidonium, Prodigiosan and Myelopid). With the help of an experimental model, morpho-functional and ultrastructural changes in the cells of the target organs were established, which indicate the development of early signs of the immune dysfunction syndrome. The work developed an algorithm of treatment and diagnostic tactics for victims with traumatic injuries of the spleen, improved the system of forecasting its results, developed a standardized rational scheme of pathogenetic intensive care of victims with inclusion of immunocorrectors, which reduces the further development of post-splenectomy syndrome and a syndrome of immunological dysfunction, reduces mortality from 18.4% to 2.1%, reduce the frequency of postoperative complications from 62.7% to 12.4%, and purulent-septic complications - from 24.1% to 8.7%.