Khmil Dosvald A. Optimization of cryoprotocols in endocrine infertility patients with polycystic ovary syndrome against the background of chronic endometritis

The dissertation summarizes and proposes an innovative solution to the research question of increasing the effectiveness of infertility treatment in women with polycystic ovary syndrome and chronic endometritis. Based on comprehensive anamnestic and clinical study, the new findings were obtained regarding the features of the clinical picture, laboratory data, endometrial structure and indicators of the stimulation protocol in patients with infertility against the background of polycystic ovary syndrome and chronic endometritis, and the effectiveness of modified standard therapy in protocols of assisted reproductive technologies has been proven. It was established that in patients with infertility against the background of polycystic ovary syndrome and chronic endometritis, stimulation of superovulation is accompanied by a higher total dose of rFSH, duration of GnRH antagonist administration, and duration of controlled ovulatory stimulation, while a significantly lower number of oocytes, blastocysts, and fertilized cells of normal form was recorded compared to patients with PCOS only. The use of modified therapy in these patients in ART protocols leads to an increase in the number of follicles and obtained oocytes, improvement in their quality, as well as an increase in the number of fertilized normal shape cells, the output of blastocysts, and the number of high-class cells compared to the standard therapy. The effectiveness of the proposed modified treatment protocol on the outcomes of in vitro fertilization has been proven; in particular, the number of achieved clinical pregnancies increases, the frequency of aborted pregnancies decreases, and the percentage of term deliveries increases.