Mammadov L. The effect of mesenchymal stem cells on reparative chondrogenesis (clinical experimental study)

The dissertation is devoted to solving a pressing scientific issue in modern medicine, which is studying the effect of adipose-derived mesenchymal stem cells on reparative chondrogenesis based on experimental results and clinical trial data. The aim of the dissertation is to improve treatment outcomes for patients with cartilage trauma and degenerative dystrophic cartilage damage by means of adipose-derived mesenchymal stem cells. The results of the conducted experiment have demonstrated that adipose-derived mesenchymal stem cells are highly effective for reparative chondrogenesis stimulation in cases of both acute and chronic cartilage damage. Under the influence of adipose-derived mesenchymal stem cells, the rats of the experimental group have had reliably better morphological and morphometric parameters of cartilage regeneration than rats of the control group. Based on the clinical outcomes, the intraoperative administration of adipose-derived mesenchymal stem cells during metal osteosynthesis of intra-articular fractures of the distal femur has been proved to be highly effective regardless of the damage type. It has been found out that patients with intra-articular fractures of the distal femur who were intraoperatively administered adipose-derived mesenchymal stem cells have reliably better long-term functional treatment outcomes than patients with no adipose-derived mesenchymal stem cells administration. As a result of the intraoperative administration of adipose-derived mesenchymal stem cells, the functional indicators of knee status of patients with degenerative dystrophic knee damage have significantly improved in the long term compared to the pre-treatment indicators.