Matviienko T. Effect of water-soluble C60 fullerene on the dynamics of rat skeletal muscle reduction against mechanical injury

The work is devoted to the study the effect of water-soluble C60 fullerene on the mechanokinetic parameters of skeletal muscle contraction and blood biochemical indicators of rats at different doses of intramuscular injection (0.5; 1; 1.5 mg/kg) against the background of mechanical muscle injury, as well as on post-traumatic muscle recovery when it is combined with menthol at the same dose (1 mg/kg). It was established that muscle trauma leads to destruction of myocytes and partial immobilization of the limb and thus makes it impossible to maintain the basic mechanokinetic parameters of muscle contraction and biochemical blood indicators in the normal range. It has been shown that administration of water-soluble C60 fullerenes in vivo promotes an increase in the magnitude of muscle contraction force and stiffness compared to the control and brings the studied biochemical blood markers closer to the physiological norm. The positive synergistic effect of C60 fullerene, as a powerful antioxidant, and menthol, as an effective anesthetic, on the posttraumatic recovery of rat skeletal muscle was established for the first time. The results obtained can serve as a basis for the development of the latest C60 fullerene-based pharmaceuticals in the treatment of muscle injuries and other associated pathologies.