Lys O. Pathogenetic features of the development of immobilization stress under the conditions of adrenaline myocardial damage and its correction by L-arginine

The dissertation work is devoted to the study of features of nitric oxide system disorders, endogenous intoxication, processes of lipoperoxidation and antioxidant protection, activity of transaminases in blood and myocardium in the dynamics (1st, 3rd, 5th days) of adrenaline myocardial damage before and after the administration of L-arginine. Experimental studies were performed on 110 Wistar line white rats (males) with the weight of 0,18 – 0,2 kg, which were kept on the standard vivarium diet in Danylo Halytsky Lviv National Medical University.Adrenaline myocardial damage was induced by the method of O.O. Markova. Immobilization stress was induced by the method of P.D. Horizontova, O.I. Belousova, M.I. Fedotova.The pathogenetic features of changes in lipoperoxidation and antioxidant protection, transaminase activity, endogenous intoxication and nitric oxide system in blood and myocardium, and their active participation in the pathogenesis of adrenaline myocardial damage and immobilization stress were shown for the first time.For the first time it was established that adrenaline damage of the myocardium and immobilization stress causes the activation of oxidative processes at all periods of their development on the background of suppression of the antioxidant system with the formation of oxidative stress, especially on the 5th day of the experiment. The corrective effect of L-arginine on the disturbed indicators of metabolic processes indicates the feasibility of its further study and use in the clinic for correction of adrenaline myocardial damage and immobilization stress as well as in the development of guidelines.