Pavluk O. Metabolic risk factors for disorders of the structural and functional state of bone tissue in men with ankylosing spondylitis

The dissertation is devoted to the solution of the current problem of modern medicine, i.e. improving the diagnosis of disorders of the structural and functional state of bone tissue in men suffering from ankylosing spondylitis (AS) based on the study of indicators of mineral density and features of metabolic (osteocalcin, N-terminal propeptide procollagen type I (PINP), N-terminal telopeptide of collagen type I(NTx)) bone tissue condition, vitamin D deficiency and their relationship with the clinical course of the disease. It was found that a decrease in bone mineral density (BMD) was registered in 44 (41,9%) men suffering from AS. The study found no relationship between BMD and the form of the disease. It was established for the first time that the levels of markers of bone tissue synthesis (osteocalcin, PINP) in men with AS do not differ significantly from those of practically healthy individuals, are not related to BMD, the presence of fractures, but probably increase in people with syndesmophytes. It was established for the first time that 35 (43,2%) men suffering from AS have a vitamin D deficiency, 25 (30,9%) have an insufficient level, and in 21 (25,9%) patients it is within the normal range. The practical significance lies in establishing a theoretical understanding of the participation of metabolic (osteocalcin, PINP, NTx, vitamin D, CRP) factors in the development of osteoporosis in men with AS.