The dissertation is devoted to elucidating the pathogenetic role of oxidative and immuno-cytokine disorders in the mechanisms of development of metabolic cardiomyopathy in male rats as a result of the cardiotoxic effect of adrenaline, hypogonadism, stress and their combination. On the basis of complex experimental studies, the pathogenetic links of the development of metabolic cardiomyopathy under the influence of adrenaline, stress, hypogonadism and their combination, which include the phase of metabolic-destructive changes, inflammatory-dystrophic process, proliferative-degenerative disorders, have been determined. It was proved, that the development of inflammatory and destructive processes in the myocardium depends on disturbances of neuroregulatory processes, cytokine reactions, manifestations of oxidative stress, pathogenetic relationships between them and pathomorphological changes that characterize the development of this pathological process. It was determined the peculiarities of changes in the blood and heart of rats of oxidative processes and endogenous intoxication during stress, hypogonadism and their combination. At the same time, it was established, that long-term stress and hypogonadism in rats cause the development of nitro-oxidative stress, the expression of which is greater during stress, and their combination causes the predominant development of carbonyl stress. The periods of the greatest accumulation of lipid peroxidation products were determined (after 1 day – in rats that were subjected to stress and castration, and starting from 7 days – in animals of the control series). At the same time, it was established that the highest levels of TBA-active products are noted in the blood of rats that have experienced stress and a control series of animals. Animals with hypogonadism show the greatest degree of increase in oxidative modification of proteins, but their highest rates are found in rats that have undergone combined pathology. The regularities of changes in superoxide dismutase and catalase activity, ceruloplasmin content in animals with epinephrine cardiomyopathy that underwent castration and stress were established. The patterns of cytokine profile changes in animals with epinephrine cardiomyopathy that underwent castration, stress, and their combination were established.
