Shanyhin A. Hygienic justification of the prevention system insufficiency and deficiency of vitamin D in the population southern Ukraine

The dissertation is devoted to the improvement and hygienic substantiation of the system for the prevention of insufficiency and deficiency of vitamin D in the population of the south of Ukraine based on the study of its prevalence and the assessment of the peculiarities of actual nutrition. Scientific novelty of the obtained results. For the first time, an analysis of seasonal fluctuations in vitamin D levels in residents of the southern regions of Ukraine, depending on gender and age, was carried out in different seasons of the year. For the first time, a hygienic assessment of the prevalence of vitamin D deficiency states associated with dyslipidemia in the adult population of southern Ukraine was performed. For the first time, the dependence of the prevalence of deficiency and insufficiency of vitamin D on the diet of residents of the southern region of Ukraine was determined. A statistical analysis of the degree of dependence of the vitamin D level on anthropometric indicators, such as body mass index and the ratio of waist circumference to hip circumference, was carried out. For the first time, the effectiveness of dietary correction of vitamin D deficiency and insufficiency among residents of southern Ukraine has been substantiated. For the first time, the criteria for forecasting and early diagnosis of the risk of vitamin D deficiency based on anthropometric and laboratory indicators have been determined. The practical significance of the results. A system of alimentary correction of vitamin D deficiency and insufficiency among residents of southern Ukraine has been developed and substantiated. A mathematical model was proposed to assess the prognosis of the risk of vitamin D deficiency states in order to assess the level of influence of selected anthropometric and laboratory indicators on the level of 25(OH)D in blood serum. Despite the fact that laboratory control of 25(OH)D is the most informative indicator of determining the status of vitamin D in the body, the use of a mathematical model makes it possible to identify individuals at risk for further diagnosis and reduce the number of laboratory tests among people who, according to this assessment, have sufficient vitamin D level.