The administration of the nanosilver preparation to laying hens in carriers based on polymer/inorganic hybrids in doses of 0,2 and 0,4 mg/head per day with an interval of 10 days showed an effect on individual indicators of protein, carbohydrate, lipid and mineral metabolism, the intensity of expression of which decreased over time. The dose of nanosilver, which was 0,2 mg/head per day, caused
a more pronounced effect on the metabolic status of the body of laying hens during one and two applications with an interval of 10 days, than the dose of 0,4 mg/head per day. The silver nanopreparation at a dose of 0.4 mg/head per day increased the content of silver by 27 % and copper by 1,9 times, but did not affect the content of zinc, iron and lead in the shell of chicken eggs 10 days after the first drinking compared to the control. Twice drinking of the nanosilver drug in carriers based on polymer/inorganic hybrids at a dose of 0,2 mg/head per day to laying hens caused a 9-fold increase in the content of silver in the eggshell compared to the control, but did not affect the content of copper, zinc, iron and of lead compared to the control. Increasing the dose of the nanosilver preparation to 0,4 mg/head per day in drinking water for chickens at two times of drinking increased the silver content in eggshells by 11 times compared to the control at stable levels of copper, zinc, iron and lead compared to the control. The mineral composition of the shell of chicken eggs after drinking a solution of the nanosilver preparation three times to laying hens also underwent changes that related only to the content of silver in the shell, in particular, a dose of 0,2 mg/head per day caused a 6,3-fold increase in the content of silver in the eggshell, and a dose of 0,4 mg/head per day increased the silver content in eggshell by 10,1, but did not affect the level of the remaining mineral components. A single administration of a nanosilver preparation to laying hens in carriers based on polymer/inorganic hybrids at a dose of 0,2 mg/head per day contributed to an increase in the silver content in egg whites by 24 %, and up to at 0,4 mg/head had no effect on silver accumulation, and both doses did not alter copper, zinc, iron, and lead contents compared to controls. Three times drinking of the nanosilver drug in carriers based on polymer/inorganic hybrids at doses of 0,2 and 0,4 mg/head per day to laying hens increased the accumulation of silver in egg white almost 2 times compared to the control, but did not affect the copper content , zinc, iron and lead in this part of the egg. Three times the use of nanosilver in carriers based on polymer/inorganic hybrids to laying hens showed a more pronounced effect on the mineral composition of egg yolks, which was manifested by an increase in the content of silver in the yolks at a dose of 0,2 mg/head per day by 1,8 times, and at doses of 0,4 mg/head per day – 2,2 times compared to the control. A single drinking of a solution of the nanosilver drug in carriers based on polymer/inorganic hybrids in doses of 0,2 and 0,4 mg per hen per day to laying hens increased its accumulation in the yolks of chicken eggs after 10 days to 44,5 and 47,5 % in the shell. The silver content in the eggshells of laying hens that received a solution of the nanosilver drug in doses of 0,2 and 0,4 mg/head per day increased to 0,39 and 0,49 μg, respectively. The third administration of the nanosilver preparation to laying hens in carriers based on polymer/inorganic hybrids in doses of 0,2 and 0,4 mg per hen per day contributed to the redistribution of the share of silver between the white and yolk of eggs as follows: in the yolk, an addition of 7 %. increasing its protein content to 14,3 and 9,4 %. Preparation of nanosilver in carriers based on polymer/inorganic hybrids, which was applied to laying hens in doses of 0,2 and 0,4 mg/head per day three times with an interval of 10 days, does not have a negative
effect on microbial composition of eggs, and also allows to preserve the symbiotic microflora of the digestive system as much as possible.
