Homeliuk T. Prediction of remote consequences of community-acquired pneumonia caused by COVID-19, depending on the Charlson comorbidity index

The dissertation provides a new, scientifically based theoretical generalization and solves the current task, which consisted in establishing the main laboratory changes in community-acquired pneumonia of different complexity categories caused by SARS-CoV-2, depending on the comorbid burden and predicting the quality of life in 1 year after discharge. The laboratory parameters of patients with community-acquired pneumonia of different categories of complexity caused by SARS-CoV-2 were analyzed, depending on the burden of the comorbidity and the methods of statistical analysis were used to predict the quality of life in persons with pneumonia caused by COVID-19, in 1 year after discharge. Scientific data on the peculiarities of the course of community-acquired pneumonia caused by SARS-CoV-2 have been supplemented, in particular, the significant influence of a high comorbid burden on the level of erythrocytes, leukocytes and ESR in patients with pneumonia is revealed. Acute-phase indices of inflammation, as well as indices of carbohydrate, hepatic metabolism, and renal profile significantly increase with increasing of pneumonia complexity and are directly associated with the Charlson index. A decrease in the quality of life of patients was established in 1 year after the community-acquired pneumonia of the 3rd and 4th category of complexity caused by SARS-CoV-2, while the general health status of such individuals with a high index of comorbidity was significantly lower compared to data with a low Charlson index. The association of increased acute-phase indices of inflammation, indices of a general blood test, renal profile in the acute period of the disease with a decrease in the physical component of health in 1 year after discharge from a hospital in patients with community-acquired pneumonia due to COVID-19 was proven. The performed ROC analysis proved that a comorbidity index of less than 3 points in the acute period of the disease is a marker of poor quality of life in patients with pneumonia due to COVID-19 in 1 year after discharge.