Al-Jarrah O. Optimization of modern approaches to the treatment of wet age-related macular degeneration, taking into account clinical and biomolecular markers

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0823U101316

Thesis Registration Form

0823U101316.pdf

Applicant for

Specialization

  • 222 - Медицина

05-12-2023

Specialized Academic Board

ДФ 05.600.082

Vinnytsia National Pirogov Memorial Medical University

Essay

The dissertation is dedicated to the solution of the actual problem of modern ophthalmology – optimization of modern approaches to the treatment of wet age-related macular degeneration (AMD) based on a complex analysis of polymorphisms pathogenetic value (rs11200638 of HTRA1 gene, rs2010963 of VEGFA gene, rs1800629 of TNF gene). For the first time in the population of the Podilsk region of Ukraine, the relationship between the clinical effectiveness of anti-VEGF therapy in patients with the "wet" form of AMD with single-nucleotide polymorphisms rs11200638 of the HTRA1 gene, rs2010963 of the VEGFA gene, and rs1800629 of the TNF gene was determined. As a result of the study, it was found that after a course of antiangiogenic therapy using the drug aflibersept in patients with a "wet" form of AMD, resistance to treatment was observed in 33.4% of cases. The average value of visual acuity in patients after treatment increased statistically significantly. The results of the analysis of the individual response to antiangiogenic therapy according to anatomical criteria in different areas of the retina revealed a tendency towards more pronounced resistance in the OKT8 area (inner temporal area) – 40.74% of eyes (p = 0.07). The association of ONP with rs2010963 of the VEGFA gene, rs11200638 of the HTRA1 gene, and rs1800629 of the TNF gene with the risk of developing a "wet" form of AMD in residents of the Podilsk region of Ukraine is shown. No statistical significance was found for the association of ONP rs11200638 of the HTRA1 gene with the response to treatment with aflibercept in patients with "wet" AMD. The relationship between the response to a full course of anti-VEGF therapy and ONP rs2010963 of the VEGFA gene was revealed in a recessive inheritance model.

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Research papers

Малачкова Н. В., Осама Мохаммад Мітеб Аль-Джаррах. (2022). Вивчення впливу поліморфізму rs1800629 TNF на перебіг вікової макулярної дегенерації крізь призму anti-VEGF терапії. Вісник Вінницького національного медичного університету, 26(2). 267–273.

Малачкова Н. В., Осама Мохаммад Мітеб Аль-Джаррах. (2022) Вплив поліморфізму rs2010963 гена VEGFA на відповідь лікування «вологої» форми вікової макулярної дегенерації. Вісник Вінницького національного медичного університету. 26(3). 411–417.

Малачкова, Н. В., Осама Мохаммад Мітеб Аль-Джаррах (2022). Роль поліморфізмів генів HTRA серинової пептидази 1, фактора росту ендотелію судин, фактора некрозу пухлин у лікуванні «вологої» форми вікової макулярної дегенерації. Львівський клінічний вісник. 3(39) – 4(40), 45–53.

Малачкова Н. В., Маса’дех, М. М. М., Аль-Джаррах О. М. М., Людкевич Г. П., Сухань Д. С. (2021). Сучасний погляд на етіопатогенез вікової макулярної дегенерації та роль молекулярно-генетичних детермінант у ньому. Архів офтальмології України, 9(3), 21-27.

Malachkova N. V., Osama Mohammad Miteb Al-Jarrah. (2022) Study of Susceptibility To The Occurence of Age-related Macular Degeneration on The Basis of The VEGF Gene Polymorphism. Proceedings of X International Scientific and Practical Conference «Eurasian Scientific Discussions» (23-25 жовтня 2022 р., м. Барселона, Іспанія). С. 38–43.

Malachkova N. V., Osama Mohammad Miteb Al-Jarrah. (2022) Study of Susceptibility To The Occurence of Age-related Macular Degeneration on The Basis of The HTRA1 Gene Polymorphism. Proceedings of VIII International Scientific and Practical Conference «Modern Research in World Science» (29-31 жовтня 2022 р., м. Львів, Україна). С. 126–131.

Malachkova N. V., Osama Mohammad Miteb Al-Jarrah. (2022). Study of Susceptibility To The Occurence of Age-related Macular Degeneration on The Basis of The TNF Gene Polymorphism. Proceedings of II International Scientific and Practical Conference «Scientific Progress: Innovations, Achievements and Prospects» (6-8 листопада 2022 р., м. Мюнхен, Німеччина). С. 43–49.

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