Lung cancer is the leading cause of death from malignant neoplasms in both men and women. According to GLOBOCAN data, 2.2 million new cases of the disease and 1.8 million deaths from this pathology were registered worldwide in 2020. Despite the complexity of performed measures (radical surgery and adjuvant chemotherapy), approximately 30% of radically treated patients have lung cancer recurrence within the first five years. The average duration of the recurrence-free period is 15.7 months. The dissertation is devoted to studying predictors of recurrence of non-small cell lung cancer in radically operated patients with stages IB – IIIA who received courses of adjuvant chemotherapy or chemoradiotherapy. The following methods were used to analyze and process the research results: clinical data (patient age, sex, smoking status, categories T, N, disease stage, ECOG status, type of surgical intervention); laboratory results (blood count tests); histological ( histological variant and histopathological grading of the tumor, lymphovascular invasion); immunohistochemical (expression level of PD-L, Ki67, p53, EGFR and ALK markers); statistical (ROC analysis, univariate and multivariate Cox regression analysis, Kaplan-Meier method). The retrospective study was based on the medical histories and outpatient records of 104 patients who received radical surgical treatment and adjuvant chemotherapy for stage IB-IIIA non-small cell lung cancer. Based on the results obtained during the work on the dissertation research, a questionnaire was developed for medical professionals, which allows the assessment of the degree of risk of disease recurrence in patients with IB-IIIA stages of the disease at the stage before adjuvant chemotherapy or chemoradiotherapy. In addition, the optimal CT scan mode during the observation period was determined. Public clinical and laboratory indicators were used to conduct the study and determine predictors of lung cancer recurrence. Despite many publications on the prediction of lung cancer recurrence, most studies have been conducted in Asian populations. Such a study among Ukrainians was conducted for the first time. The obtained data are of socio-economic importance, as they allow identifying high-risk patients at the stage after radical treatment but before the start of specialized drug therapy. At this stage, it is possible to personalize the diagnostic process (further molecular genetic research), the treatment process (increasing the number of chemotherapy courses, choosing a more aggressive chemotherapy regimen, choosing targeted or immunotherapy), as well as more careful observation of the patient (performing PET-CT, expanding the list CT scan areas required for research, a thorough examination by an oncologist and a family doctor, etc.). The listed measures will minimize treatment costs associated with lung cancer recurrence and patient disability. The dissertation research can be used as educational and methodological literature during the training of specialists in oncology, thoracic surgery, and pathological anatomy.
