Ivanchuk I. Structural and functional changes of the cerebral cortex in terms of experimental oncogenesis and under conditions of nanomaterials correction application

The dissertation is devoted to broad investigation of structural and functional alterations sensory area of the cerebral cortex, metabolic disorders, and changes of the colon microbiome taxonomic composition caused by experimental DMG-induced colon adenocarcinoma in situ. This study also evaluates effectiveness of the gold, silver and iron nanoparticles composition (Au/Ag/Fe NPs) for the correction of the detected disorders. The peculiarities of structural and functional changes in the cerebral cortex of experimental animals in terms of induced oncogenesis at the cellular and subcellular levels were investigated, with the use of modern experimental methods. We also identified that alternative changes in neurocytes and disturbances in their intracellular spatial characteristics develop on the background of severe metabolic disorders and disturbances in the qualitative and quantitative composition of the colon microbiome. At the same time, the features of microscopic, submicroscopic and morphometric changes in the studied structures, their particularities and sequence of manifestation change in the dynamics of the development of the nonplastic process and depend on the duration of carcinogen exposure. The peculiarities of structural and functional changes in the cerebral cortex of experimental animals in terms of induced oncogenesis at the cellular and subcellular levels were investigated first proven with the use of modern experimental methods set. It also was found that alternative changes in neurocytes and disturbances in their intracellular spatial characteristics develop on the background of severe metabolic disorders of the qualitative and quantitative composition of the colon microbiome. At the same time, the nature of microscopic, submicroscopic and morphometric changes in the studied structures, their stages and sequence of manifestation changed in the dynamics of the development of the neonplastic process and depened on the duration of carcinogen exposure.