Redko O. Morphofunctional state of the liver during acute respiratory distress syndrome and its treatment by mesenchymal stem cells

The dissertation is dedicated to the comprehensive study of the structural components and functional activity of the liver in rats with experimental acute respiratory distress syndrome (ARDS) and during the use of human umbilical cord mesenchymal stem cells (MSC). For the first time in Ukraine, the development of liver injury during simulated ARDS in rats has been analyzed. Histological, ultramicroscopic, immunohistochemical, biochemical studies established the stages of pathological changes in the liver in the experimental ARDS model. The hepatoprotective and regenerative effects of MSC in ARDS-induced liver injury in rats have been comprehensively studied. It has been established that human umbilical cord MSCs do not exhibit immunogenic effects on the liver tissues of rats. Based on the results of histological, immunohistochemical, electron microscopic, biochemical, and statistical analyses, the anti-inflammatory, antifibrotic, and immunomodulatory activities of the investigated MSC were demonstrated. The immunomodulatory effect of MSC was manifested in the transformation of macrophages towards the anti-inflammatory M2 phenotype.