The study of the peculiarities of the gestational process in women with risk of miscarriage is extremely important. The incidence of this pathology is up to 25% of all pregnancies (i.e. potentially one in four women may have a pregnancy loss). Perinatal losses have a significant impact on the physical and psychological health of women. Therefore, it is important to diagnose threatening conditions in early pregnancy and treat them in timely manner. Disorders of the mother-placenta-fetus system and placental dysfunction, which is formed against this background, play an essential role in the genesis of miscarriage. At the same time there are disorders of all functions of the placental system, including antitoxic, endocrine, transport, metabolic, trophic. All this leads to an inappropriate intake of oxygen and nutrients into the fetus's body, which are necessary for full growth and development. Fetal hypoxia, a slowdown in its weight gain during intrauterine development are usually combined with damage or underdevelopment of the central nervous system, which later manifests itself in a violation of the child's adaptation during the neonatal period, an increased risk of disease, and at a later age - in impaired physical and intellectual development of children. Consequently, our study aimed to optimize methods for diagnosing and treating miscarriages based on studying the characteristics of maternal-fetal relationships.
The developed criteria for early complex diagnostics and individualized pathogenetically grounded therapeutic measures for pregnant women with miscarriage made it possible to identify pathological changes in the functioning of the mother-placenta-fetus system already in the early stages of gestation, select an individual scheme for correcting disorders and reducing the amount of placental dysfunction. 2 times, which contributed to the improvement of the course and prolongation of pregnancy, as well as the birth of healthy children.
The obtained data are the theoretical basis for further experimental and clinical research, in particular in obstetrics, gynecology, pathological anatomy, histology, genetics. The results of the study can be used as a theoretical justification for diagnostic and screening methods for early diagnosis of disorders of the fetoplacental complex in women with a burdensome obstetric history. The developed treatment scheme should be actively implemented in practice, which will significantly improve the course of pregnancy in women with a history of miscarriage and prevent perinatal losses.
