Mykhailova O. Optimization of diagnosis and correction of hypotaminosis D in children with paralytic syndromes during the COVID-19 pandemic

The thesis is devoted to the improvement of diagnostics and optimization of correction of hypovitaminosis D in children with paralytic syndromes during the COVID-19 pandemic, with a pathway for the detection of 25(OH)D in the blood serum before the post-implantation of vitamin D3. The object of study was hypovitaminosis D (deficiency and insufficiency of vitamin D). The methodology of carrying out the study was formed from several stages, the skins of which were implemented in order to complete the task of work and form the design of the study. For the design follow cross-section, simple, description, for the type of "case-control", prospective and retrospective. Hypotheses were put forward: 1) children with severe and critical COVID-19 have hypovitaminosis D; 2) children with paralytic syndromes have hypovitaminosis D and reduced physical activity during the COVID-19 pandemic compared to peers without paralytic syndromes. The material for the epidemiological study during the cross-sectional period was 393 cases of diseases and conditions in the intensive care unit. In order to determine risk factors for hypovitaminosis D in children with paralytic syndromes, a timely survey of parents using the "Questionnaire for determining risk factors for the development of hypovitaminosis D" is proposed. A risk factor for the development of hypovitaminosis D in children with paralytic syndromes, which is related to the way of life, was determined: the number of days spent walking outdoors on a fresh day (OR 14.5) and walking on the streets less than a year per day (OR 43.7), impossibility to independent ruptures (OR 43.7). The risk factor for hypovitaminosis D in children with paralytic syndromes in children with neurological disorders without paralytic syndromes was the number of days of self-reliance (RR 4.3) and the intake of drugs (RR 2.3). The COVID-19 pandemic has changed the way children with paralytic syndromes live: a change in accessibility to rehabilitation mortgages during the lockdown (OR 4.1), a change in walks on the streets (OR 1.8), a change in the availability of the COVID-19 pandemic at the seaside -19 (OR 3.9). Recommendations for optimizing the diagnosis and correction of hypovitaminosis D in children with paralytic syndromes during the COVID-19 pandemic have been elaborated. In order to prevent the development of hypovitaminosis D in children with paralytic syndromes during the COVID-19 pandemic, it is recommended to run a multiply system of assistance with a trained physical therapist and social services. New approaches have been proposed for optimizing the diagnosis and treatment of pain in children with paralytic syndromes, which improves the quality of life of children with paralytic syndromes and their symptoms.