Korota Y. Physical therapy of patients with coronavirus diseases at rehabilitation stages

The dissertation presents a theoretical substantiation and addresses the scientific and practical task of enhancing the effectiveness of physical rehabilitation for patients with pneumonia associated with coronavirus disease. This is achieved by developing and substantiating a physical therapy program for the post-acute and long-term periods, taking into account clinical manifestations, the risk of thromboembolic complications, chest mobility, cardiorespiratory endurance, and biochemical markers. To achieve this goal, clinical, instrumental, laboratory, functional, and statistical research methods were used The study is the first to demonstrate that considering the body's response, particularly the dynamics of arterial blood hemoglobin oxygen saturation (SpO2) in response to graded physical exercise, is effective in restoring cardiorespiratory endurance and addressing functional limitations in patients with pneumonia associated with coronavirus disease during the post-acute rehabilitation period. It is also the first to prove the positive impact of therapeutic exercises on the quality of life of patients with coronavirus disease in the long-term rehabilitation period, particularly on physical functioning indicators. Furthermore, it is the first to identify and quantitatively define prognostic factors for the effectiveness of rehabilitation in restoring cardiorespiratory endurance in patients with pneumonia associated with coronavirus disease. Specifically, the most significant negative prognostic factor for restoring cardiorespiratory endurance in the post-acute rehabilitation period is the duration of the «Timed Up and Go» test, while the strength of the upper limb muscles is a favorable prognostic factor. Additionally, the level of C-reactive protein and transforming growth factor β negatively impact the effectiveness of long-term rehabilitation, whereas the overall level of physical functioning, as measured by the SF-36 questionnaire, has a positive impact