Chaulagain D. Prognostic Factors Influencing Clinical Outcome in Surgically Treated Glioblastoma

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0824U003103

Thesis Registration Form

0824U003103.pdf

Applicant for

Specialization

  • 222 - Медицина

29-10-2024

Specialized Academic Board

ДФ 61.051.131

Uzhhorod National University State Higher Educational Institution

Essay

This thesis aims to identify prognostic factors associated with surgical resection of glioblastoma and their impact on treatment outcomes. Given the poor prognosis of glioblastoma and the short overall survival time, understanding these factors is crucial to improve treatment protocols and improve the quality of life of patients. The study is retrospective, covering a 10-year period with a median follow-up of 36 months, and uses comprehensive statistical and scientific analysis to provide reliable results. The study highlights the practical relevance of how tumour-related factors and technical aspects can influence the extent of resection in glioblastoma. The findings emphasise the importance of modern technology for safer tumour removal and adequate assessment of residual tumours after surgery. Identifying tumour-specific or treatment-related factors that influence the optimal resection volume will be important in developing techniques for the safest possible removal of glioblastomas. The study advocates the integration of advanced technologies to address the problems associated with insufficient tumour removal, thereby improving the accuracy of surgical intervention. Using modern technologies to enhance surgical strategy has a proven impact on improving clinical outcomes for patients with glioblastoma. The independent experts' positive conclusions confirm the proposed innovations' effectiveness and provide every reason for their implementation in glioblastoma treatment protocols. The study results, reflected in ten scientific papers and presented at international scientific conferences, are an important addition to the evidence-based information on this complex and unsolved problem of modern medicine.

Read more

Research papers

1. Chaulagain, D., Smolanka, V., Smolanka, A., & Havryliv, T. (2022). Gross total resection in a rare case of optic nerve astrocytoma: a case report. Wiadomości Lekarskie (Warsaw Poland), 75(9), 2299–2303.

2. Chaulagain, D., Smolanka, V., Smolanka, A., Havryliv, T., Nassar, A., & Ayasi, M. (2023). A monocenter retrospective study of the surgical outcomes of adult pilocytic astrocytoma. A small case series and review of the literature. International Neurological Journal, 18(8), 11–14.

3. Chaulagain, D., Smolanka, V., & Smolanka, A. (2022). A comprehensive review of low-grade diffuse astrocytoma: characteristics, molecular classification and surgical treatment. International Neurological Journal, 18(4), 39–45.

4. Chaulagain, D., Smolanka, V., Smolanka, A., & Havryliv, T. (2023). Glioblastoma: a literature review. International Neurological Journal, 18(8), 32–37.

5. Chaulagain, D., Smolanka, V., & Smolanka, A. (2022). Pilocytic astrocytoma: a literature review. International Neurological Journal, 18(3), 39–45.

6. Chaulagain, D., Smolanka, V., Smolanka, A., & Havryliv, T. (2022). Role of extent of resection for the surgical outcome in low-grade oligoastrocytoma: a case study. International Neurological Journal, 18(2), 10–14.

7. Chaulagain, D., Smolanka, V., & Smolanka, A. (2022). Diagnosis and management of astrocytoma: a literature review. International Neurological Journal, 18(1), 23–29.

8. Chaulagain, D., Smolanka, V., Smolanka, A., Munakomi, S., & Havryliv, T. (2022). The role of extent of resection on the prognosis of low-grade astrocytoma: a systematic review and meta-analysis. Egyptian Journal of Neurosurgery, 37(1).

9. Chaulagain, D., Smolanka, V., Smolanka, A., & Havryliv, T. (2021). The impact of extent of resection in surgical outcome of pilomyxoid astrocytoma: a case study. Ukrainian Neurosurgical Journal, 27(4), 43–48.

10. Chaulagain, D., Smolanka, V., Smolanka, A., & Havryliv, T. (2023). Advancements in surgical management of glioblastoma: current trends and promising future directions. International Neurological Journal, 19(5), 155– 159.

Read more

Similar theses

0824U003089

Oleksiy Y. Sukhin

Treatment of complicated and chronic injuries of the rotator cuff of the shoulder

0824U003064

Oleksii S. Khimich

Morphological and microbiological substantiation of the effectiveness of the use of an immunomodulator with an antiseptic in the treatment of infected and purulent wounds in an experiment.

0824U003070

Tariel R. Kerimov

Morpho-functional changes of gastric glandulocytes in an experimental model of diabetes mellitus type 2 and pharmacological correction

0824U003040

Yevhen Samokhin

Evaluation of Biocompatibility and Antibacterial Efficiency of Three-Dimensional Fibrous Materials with Incorporated Nanoparticles

0824U003013

Oleksandra S. Kozyra

Individualization of embryo transfer in the treatment of women with uterine factor infertility.