Mahiiovych S. Clinical and pathogenetic features of kidney damage in patients with coronavirus disease and their correction

ANNOTATION Mahiiovich S.R. Clinical and pathogenetic Features of kidney damage in patients with coronavirus Disease and their correction. - Qualification scientific work on the rights of a manuscript. Dissertation for the degree of Doctor of Philosophy in the specialty 222 Medicine (22 – Health Care). - Danylo Halytskyi Lviv National Medical University, Ministry of Health of Ukraine, Lviv, 2025. The relevance of the study is due to the problem of high in-hospital mortality from coronavirus disease (COVID-19), especially among patients with comorbidities. The perception of COVID-19 by the medical community as a respiratory infection led to underestimating the role of kidney function during treatment, which in turn was a risk factor for severe course and death. This dissertation is devoted to the study of clinical, anamnestic, pathogenetic, and laboratory-instrumental features of the course of coronavirus disease depending on the presence of renal dysfunction determined by the glomerular filtration rate (GFR) and nephropathy associated with arterial hypertension and/or type 2 diabetes mellitus (T2DM). The aim of the dissertation research was to optimize the diagnosis of kidney function in patients with coronavirus disease based on the results of clinical, anamnestic, and laboratory-instrumental studies during inpatient treatment. To achieve this goal, the following tasks were set: to analyze the clinical, anamnestic, and laboratory features of the course of coronavirus disease in patients with lung damage and renal dysfunction; to establish the level of mortality and the influence of various factors on this level among hospitalized patients with coronavirus disease; to compare the results of clinical, laboratory, and instrumental studies in patients with coronavirus disease and nephropathy associated with arterial hypertension and/or type 2 diabetes mellitus; to compare the indicators of gas transmitter activity in patients with coronavirus disease and nephropathy associated with arterial hypertension and/or type 2 diabetes mellitus; to identify and compare the pathohistological signs of kidney damage in deceased patients diagnosed with COVID-19 and nephropathy associated with arterial hypertension and/or type 2 diabetes mellitus. The object of the study: renal dysfunction, nephropathy, coronavirus disease with lung damage, type 2 diabetes mellitus, glomerular filtration rate, cystatin C. The subject of the study: kidney damage in coronavirus disease, the course of coronavirus disease, changes in the pro-inflammatory, coagulation status during treatment of coronavirus disease, cystatin C concentration, glomerular filtration rate, gas transmitter activity.