Plakhotna O. The clinic-immunological pecularitues of meningitis in newborns.

The detailed analysis neurological of the status newborn in the various periods of disease, with parallel study paraclinical of parameters, including immunological of researches, both general (common), and local (CSF) of immunity is made. Is established, that in the period of newborn in development meningitis the important role play antenatal and intranatal a defeat CNS (chronic infections at the mother, hypoxic-ischemic and traumatic a defeat of a brain / ante- and intranatal the defeat of a brain) on which background occurs microbial invasion more easily. In early neonatal the period are diagnosed purulent meningitis, in late neonatal the period alongside with purulent, frequently come to light serious (virus) meningitis. The expediency of study immunological of the status, which in the acute period was characterised by dysfunction of T- and B - lymphocytes (reduction of their total, infringement of their functional activity in RBTL, decrease of a level IgG, IgM, IgA produce rise), and also increase in CSF IgG and IgM, IgA emergence. The diagnostic value USI and computer tomography in the characteristic of cerebrum structures in case of meningitis. The recommendations for perfection antimicrobial and immunomodellity of therapy with the account aetiology of clinical variants meningitis and condition immunobiological reactivity newborn are offered.